A Facile Route to 4-Polyfluoroarylquinolin-2(1H)-ones and 4-Polyfluoroarylcoumarins via C-H Bond Activation

Palladium-catalyzed cross-coupling reaction of 4-trifloxy-quinolin-2(1H)-ones or 4-chlorocoumarins with polyfluoroarenes has been successfully developed. Under mild conditions, the reactions afforded 4-polyfluoroarylquinolin-2(1H)-ones and 4-polyfluoroarylcoumarins, which feature a wide range of bio...

Full description

Saved in:
Bibliographic Details
Published inChemistry letters Vol. 46; no. 8; pp. 1223 - 1226
Main Authors Fang, Ling, Xue, Lijun, Yang, Peng, Li, Xiaodan, Wang, Zhiyong
Format Journal Article
LanguageEnglish
Published TOKYO Chemical Soc Japan 05.08.2017
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
4-PHENYLCOUMARINS
DIRECT ARYLATION
3-HYDROXYQUINOLIN-2(1H)-ONES
ELECTRON-DEFICIENT POLYFLUOROARENES
Quinolin-2(1H)-one
EFFICIENT SYNTHESIS
Coumarin
QUINOLIN-2(1H)-ONES
CROSS-COUPLINGS
4-SUBSTITUTED COUMARINS
Polyfluoroarene
INHIBITOR
ALKENYLATION
Online AccessGet more information

Cover

More Information
Summary:Palladium-catalyzed cross-coupling reaction of 4-trifloxy-quinolin-2(1H)-ones or 4-chlorocoumarins with polyfluoroarenes has been successfully developed. Under mild conditions, the reactions afforded 4-polyfluoroarylquinolin-2(1H)-ones and 4-polyfluoroarylcoumarins, which feature a wide range of bioactive compounds, with good yields.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.170466