Differences in vascular response between primary and transplanted tumours

The vast majority of studies on tumour vasculature are performed on transplanted tumours in rodents. However, it is known that there may be differences between primary and transplanted lesions. The purpose of this study is to test whether a specific vascular response is similar in primary tumours an...

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Published inBritish journal of cancer Vol. 63; no. 5; pp. 723 - 726
Main Authors FIELD, S. B, NEEDHAM, S, BURNEY, I. A, MAXWELL, R. J, COGGLE, J. E, GRIFFITHS, J. R
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing Group 01.05.1991
Subjects
Animal tumors. Experimental tumors
Animals
Biological and medical sciences
Experimental tumors, general aspects
Fibroma - blood supply
Fibrosarcoma - blood supply
Histiocytoma, Benign Fibrous - blood supply
Hydralazine - pharmacology
Magnetic Resonance Spectroscopy
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Neoplasm Transplantation
Neoplasms, Radiation-Induced - blood supply
Phosphorus
Regional Blood Flow - drug effects
Skin Neoplasms - blood supply
Skin Neoplasms - etiology
Tumors
Vertebrata
Mammalia
Mouse
Animal
Rodentia
Primary
Tumor
NMR spectrometry
Homotransplantation
Vascularization
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Summary:The vast majority of studies on tumour vasculature are performed on transplanted tumours in rodents. However, it is known that there may be differences between primary and transplanted lesions. The purpose of this study is to test whether a specific vascular response is similar in primary tumours and in transplanted tumours derived from them. The technique used was to give an intraperitoneal injection of 5 mg kg-1 hydralazine, which is known to result in hypoxia in transplanted tumours. Changes in perfusion were indicated by changes in metabolism, monitored using 31P Magnetic Resonance Spectroscopy. The primary tumours were induced by local irradiation many months previously and only 4/11 (36%) of these responded to hydralazine. One of the non responders was subsequently transplanted into isogeneic mice to produce a tumour line which was histologically very similar to the primary. Of these 16/17 (94%) responded. The difference is statistically significant (P = 0.001). The reasons for this difference are not known. A number of possibilities are discussed and in the authors' opinion, the most likely cause is that it results from an artefact of transplantation.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1991.163