Current understanding of thalamic structure and function in migraine

Objective To review and discuss the literature on the role of thalamic structure and function in migraine. Discussion The thalamus holds an important position in our understanding of allodynia, central sensitization and photophobia in migraine. Structural and functional findings suggest abnormal fun...

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Bibliographic Details
Published inCephalalgia Vol. 39; no. 13; pp. 1675 - 1682
Main Authors Younis, Samaira, Hougaard, Anders, Noseda, Rodrigo, Ashina, Messoud
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.11.2019
Subjects
allodynia
functional connectivity
Migraine
pain processing
sensitization
photophobia
thalamus
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Summary:Objective To review and discuss the literature on the role of thalamic structure and function in migraine. Discussion The thalamus holds an important position in our understanding of allodynia, central sensitization and photophobia in migraine. Structural and functional findings suggest abnormal functional connectivity between the thalamus and various cortical regions pointing towards an altered pain processing in migraine. Pharmacological nociceptive modulation suggests that the thalamus is a potential drug target. Conclusion A critical role for the thalamus in migraine-related allodynia and photophobia is well established. Additionally, the thalamus is most likely involved in the dysfunctional pain modulation and processing in migraine, but further research is needed to clarify the exact clinical implications of these findings.
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ISSN:0333-1024
1468-2982
1468-2982
DOI:10.1177/0333102418791595