Ki-1+ ANAPLASTIC LARGE CELL LYMPHOMA IN A CHILD WITH UNPREDICTABLE CLINICAL COURSE

• Published in: Pediatric hematology and oncology Vol. 18; no. 2; pp. 143 - 146
• Main Authors: Madero, L., Benito, A. I., Quintero, V., Gonzalez-Vicent, M., Díaz, M. A.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Informa UK Ltd 2001; Taylor & Francis
• Subjects: Adolescent; Anaplastic Large Cell Lymphoma; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Biological and medical sciences; Children; Diagnosis, Differential; Disease-Free Survival; Female; Hematologic and hematopoietic diseases; Humans; Ki-1; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Low-GRADE Lymphoma; Lymphoma, Follicular - diagnosis; Lymphoma, Follicular - drug therapy; Lymphoma, Follicular - pathology; Lymphoma, Large-Cell, Anaplastic - diagnosis; Lymphoma, Large-Cell, Anaplastic - drug therapy; Lymphoma, Large-Cell, Anaplastic - pathology; Medical sciences; Neoplasm Invasiveness; Neoplasms, Second Primary - chemistry; Neoplasms, Second Primary - drug therapy; Neoplasms, Second Primary - pathology; Non-HODGKIN Lymphoma; Recurrence; Skin Neoplasms - chemistry; Skin Neoplasms - drug therapy; Skin Neoplasms - pathology; Human; Case study; Skin disease; Low malignancy; Adolescent; Ki1 positive large cell anaplastic lymphoma; Clinical form; Female; Malignant hemopathy; Skin
• ISSN: 0888-0018; 1521-0669
• DOI: 10.1080/088800101300002982

Ki-1+ anaplastic large cell lymphoma (Ki-1+ ALCL) is a subtype of non-Hodgkin lymphoma (NHL) with defined histopathological characteristics but with highly variable clinical presentation and outcome. Although in most of the patients the disease behaves as an intermediate- or high-grade lymphoma, some patients present with an indolent clinical course. Factors that determine the clinical behavior of this lymphoma have not yet been identified. A case is reported of a 13-year-old girl who initially presented with Ki-1+ ALCL but later developed recurrent localized cutaneous disease and followed a clinical course similar to that of a low-grade lymphoma.