Implications of small-bowel transit time in the detection rate of capsule endoscopy: A multivariable multicenter study of patients with obscure gastrointestinal bleeding
AIM To define the role of small-bowel transit time in the detection rate of significant small-bowel lesions.METHODS Small-bowel capsule endoscopy records, prospectively collected from 30 participating centers in the Lombardy Registry from October 2011 to December 2013, were included in the study if...
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Published in | World journal of gastroenterology : WJG Vol. 23; no. 4; pp. 697 - 702 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
Baishideng Publishing Group Inc
28.01.2017
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Subjects | |
Online Access | Get full text |
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Summary: | AIM To define the role of small-bowel transit time in the detection rate of significant small-bowel lesions.METHODS Small-bowel capsule endoscopy records, prospectively collected from 30 participating centers in the Lombardy Registry from October 2011 to December 2013, were included in the study if the clinical indication was obscure gastrointestinal bleeding and the capsule reached the cecum. Based on capsule findings, we created two groups: P2(significant findings) and P0-1(normal/negligible findings). Groups were compared for age, gender, small-bowel transit time, type of instrument, modality of capsule performance(outpatients vs inpatients), bowel cleanliness, and center volume.RESULTS We retrieved and scrutinized 1,433 out of 2,295 capsule endoscopy records(62.4%) fulfilling the inclusion criteria. Patients were 67 ± 15 years old, and 815(57%) were males. In comparison with patients in the P0-1 group, those in the P2 group(n = 776, 54%) were older(P < 0.0001), had a longer small-bowel transit time(P = 0.0015), and were more frequently examined in low-volume centers(P < 0.001). Age and smallbowel transit time were correlated(P < 0.001), with age as the sole independent predictor on multivariable analysis. Findings of the P2 group were artero-venous malformations(54.5%), inflammatory(23.6%) and protruding(10.4%) lesions, and luminal blood(11.5%).CONCLUSION In this selected, prospectively collected cohort of small-bowel capsule endoscopy performed for obscure gastrointestinal bleeding, a longer small-bowel transit time was associated with a higher detection rate of significant lesions, along with age and a low center volume, with age serving as an independent predictor. |
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Bibliography: | Carlo Maria Girelli;Marco Soncini;Emanuele Rondonotti;Gastroenterology and Digestive Endoscopy Unit,Hospital of Busto Arsizio(VA);Gastroenterology,S. Carlo Hospital;Gastroenterology,Valduce Hospital ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Undefined-2 Author contributions: All authors provided substantial contributions to the conception, design, and/or acquisition of data, and/or the analysis and interpretation of data; Girelli CM performed the statistical analysis and wrote the manuscript; Soncini M implemented and updated the database; Rondonotti E provided intellectual content in the interpretation of study results; all authors critically revised and approved the final draft of the manuscript. Correspondence to: Carlo M Girelli, MD, Gastroenterology and Digestive Endoscopy Unit, Hospital of Busto Arsizio (VA),Via Arnaldo da Brescia, 1, 21052 Busto Arsizio (VA), Italy. cargirel@gmail.com Telephone: +39-03-31699261 Fax: +39-03-31699265 |
ISSN: | 1007-9327 2219-2840 |
DOI: | 10.3748/wjg.v23.i4.697 |