Dissolution of polydisperse ensembles of crystals in channels with a forced flow

• Published in: Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences Vol. 378; no. 2171; p. 20190246
• Main Authors: Ivanov, Alexander A, Alexandrov, Dmitri V, Alexandrova, Irina V
• Format: Journal Article
• Language: English
• Published: England The Royal Society Publishing 15.05.2020
• Subjects: microcrystals; phase transformations; particle-size distribution function; dissolution
• ISSN: 1364-503X; 1471-2962
• DOI: 10.1098/rsta.2019.0246

A non-stationary integro-differential model describing the dissolution of polydisperse ensembles of crystals in channels filled with flowing liquid is analysed. The particle-size distribution function, the particle flux through an arbitrary cross-section of the channel, the particle concentration profile, as well as the disappearance intensity of particles are found analytically. It is shown that a nonlinear behaviour of solutions is completely defined by the source term of particles introduced into the channel. In particular, the model approximately describes the processes of dissolution and transport of drug microcrystals to the target sites in a living organism, taking into account complex dissolution kinetics of drug particles. This article is part of the theme issue 'Patterns in soft and biological matters'.