The utilization of copper flow reactors in organic synthesis

The use of flow chemistry techniques has flourished over the past decade, with the field expanding to include the use of copper flow reactors in bench-top organic synthesis in recent years. These reactors are available in a variety of forms and possess a number of advantages over their batch reactio...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 51; no. 15; pp. 337 - 344
Main Authors Bao, Jennifer, Tranmer, Geoffrey K
Format Journal Article
LanguageEnglish
Published England 21.02.2015
Subjects
Carbon-carbon composites
Chemical reactions
Chemistry Techniques, Synthetic
Click Chemistry
Copper
Copper - chemistry
Couplings
Cyclization
Cycloaddition Reaction
Decarboxylation
Nuclear engineering
Nuclear safety
Reactors
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Summary:The use of flow chemistry techniques has flourished over the past decade, with the field expanding to include the use of copper flow reactors in bench-top organic synthesis in recent years. These reactors are available in a variety of forms and possess a number of advantages over their batch reaction counterparts, in terms of both safety and yield. This review will highlight the current research employing copper flow reactors, such as 1,3-dipolar cycloadditions ('click' chemistry), macrocyclizations ( via 'click' chemistry), Sonogashira C-C couplings, Ullmann couplings, decarboxylations, and other reported findings. A review which highlights the current research employing copper-metal flow reactors in bench-top organic synthesis.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc09221j