Lipoprotein(a) As a Risk Factor in a Cohort of Hospitalised Cardiovascular Patients: A Retrospective Clinical Routine Data Analysis

• Published in: Journal of clinical medicine Vol. 12; no. 9; p. 3220
• Main Authors: Šuran, David, Završnik, Tadej, Kokol, Peter, Kokol, Marko, Sinkovič, Andreja, Naji, Franjo, Završnik, Jernej, Blažun Vošner, Helena, Kanič, Vojko
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.04.2023; MDPI
• Subjects: acute myocardial infarction; Age; Antigens; aortic valve stenosis; Apolipoproteins; Atherosclerosis; cardiovascular diseases; cardiovascular risk; Cholesterol; Clinical medicine; Data analysis; Disease; High density lipoprotein; Hospitalization; ischemic heart disease; Laboratories; Low density lipoprotein; Regression analysis; Triglycerides; Womens health; atherosclerosis; postmenopausal women; aortic valve stenosis; ischemic heart disease; cardiovascular diseases; cardiovascular risk; lipoprotein(a); acute myocardial infarction
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12093220

Lipoprotein(a) (Lp(a)) is a well-recognised risk factor for ischemic heart disease (IHD) and calcific aortic valve stenosis (AVS). A retrospective observational study of Lp(a) levels (mg/dL) in patients hospitalised for cardiovascular diseases (CVD) in our clinical routine was performed. The Lp(a)-associated risk of hospitalisation for IHD, AVS, and concomitant IHD/AVS versus other non-ischemic CVDs (oCVD group) was assessed by means of logistic regression. In total of 11,767 adult patients, the association with Lp(a) was strongest in the IHD/AVS group (e = 1.010, < 0.001), followed by the IHD (e = 1.008, < 0.001) and AVS group (e = 1.004, < 0.001). With increasing Lp(a) levels, the risk of IHD hospitalisation was higher compared with oCVD in women across all ages and in men aged ≤75 years. The risk of AVS hospitalisation was higher only in women aged ≤75 years (e = 1.010 in age < 60 years, e = 1.005 in age 60-75 years, < 0.05). The Lp(a)-associated risk was highest for concomitant IHD/AVS hospitalisations. The differential impact of sex and age was most pronounced in the AVS group with an increased risk only in women aged ≤75 years.