Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined

In this trial, adults with obesity without diabetes were randomly assigned, after an 8-week low-calorie diet, to 1 year of placebo, an exercise program, liraglutide, or exercise plus liraglutide. Combined treatment with exercise and liraglutide improved healthy weight loss maintenance more than eith...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 384; no. 18; pp. 1719 - 1730
Main Authors Lundgren, Julie R, Janus, Charlotte, Jensen, Simon B.K, Juhl, Christian R, Olsen, Lisa M, Christensen, Rasmus M, Svane, Maria S, Bandholm, Thomas, Bojsen-Møller, Kirstine N, Blond, Martin B, Jensen, Jens-Erik B, Stallknecht, Bente M, Holst, Jens J, Madsbad, Sten, Torekov, Signe S
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 06.05.2021
Subjects
Adipose Tissue
Adult
Anti-Obesity Agents - adverse effects
Anti-Obesity Agents - therapeutic use
Antidiabetics
Body fat
Body Size
Body weight
Body weight loss
Caloric Restriction
Calories
Cardiorespiratory fitness
Combined Modality Therapy
Design
Diabetes mellitus
Exercise
Exercise Therapy
Female
Heart rate
Hemoglobin
Humans
Hypocaloric diet
Insulin
Insulin resistance
Liraglutide - adverse effects
Liraglutide - therapeutic use
Male
Middle Aged
Nutrient deficiency
Obesity
Obesity - diet therapy
Obesity - drug therapy
Obesity - therapy
Physical fitness
Physical training
Placebos
Statistical analysis
Weight control
Weight Loss - drug effects
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Summary:In this trial, adults with obesity without diabetes were randomly assigned, after an 8-week low-calorie diet, to 1 year of placebo, an exercise program, liraglutide, or exercise plus liraglutide. Combined treatment with exercise and liraglutide improved healthy weight loss maintenance more than either treatment alone.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa2028198