Biomarkers of the End-Stage Renal Disease Progression: Beyond the GFR

Chronic kidney disease can progress to the end-stage renal disease (ESRD) characterized by a high risk of morbidity and mortality. ESRD requires immediate therapy or even dialysis or kidney transplantation, therefore, its timely diagnostics is critical for many patients. ESRD is associated with path...

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Published inBiochemistry (Moscow) Vol. 88; no. 10; pp. 1622 - 1644
Main Authors Yakupova, Elmira I., Abramicheva, Polina A., Bocharnikov, Alexey D., Andrianova, Nadezda V., Plotnikov, Egor Y.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.10.2023
Springer
Springer Nature B.V
Subjects
Analysis
Biochemistry
Biological markers
Biomarkers
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Blood
Chronic kidney failure
Clinical medicine
Collagen
Creatinine
Development and progression
Dialysis
Disease Progression
End-stage renal disease
Endocrine disorders
Epigenetic inheritance
Epigenetics
Fibrosis
Glomerular filtration rate
Growth factors
Hemodialysis
Humans
Identification and classification
Inflammation
Kidney diseases
Kidney Failure, Chronic
Kidney transplantation
Kidney transplants
Life Sciences
Microbiology
Morbidity
Mortality
Pathology
Peptides
Proteins
Renal function
Review
Russia
kidney failure
fibrosis markers
chronic kidney disease
end-stage renal disease
kidney fibrosis
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Summary:Chronic kidney disease can progress to the end-stage renal disease (ESRD) characterized by a high risk of morbidity and mortality. ESRD requires immediate therapy or even dialysis or kidney transplantation, therefore, its timely diagnostics is critical for many patients. ESRD is associated with pathological changes, such as inflammation, fibrosis, endocrine disorders, and epigenetic changes in various cells, which could serve as ESRD markers. The review summarizes information on conventional and new ESRD biomarkers that can be assessed in kidney tissue, blood, and urine. Some biomarkers are specific to a particular pathology, while others are more universal. Here, we suggest several universal inflammatory, fibrotic, hormonal, and epigenetic markers indicative of severe deterioration of renal function and ESRD progression for improvement of ESRD diagnostics.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297923100164