Characterization of the PSG11 Gene

• Published in: Genomics (San Diego, Calif.) Vol. 22; no. 2; pp. 356 - 363
• Main Authors: McLenachan, P.A., Rutherfurd, K.J., Beggs, K.T., Sims, S.E., Mansfield, B.C.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 15.07.1994; Elsevier
• Subjects: Amino Acid Sequence; Base Sequence; Biological and medical sciences; Exons; Fundamental and applied biological sciences. Psychology; Genes; Genes. Genome; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; Multigene Family; Pregnancy-Specific beta 1-Glycoproteins - genetics; Sequence Alignment; Sequence Deletion; Sequence Homology, Nucleic Acid; Human; Molecular evolution; Gene; Nucleotide sequence; Chromosome DNA; Homology; Multigene family; Gene organization; Glycoproteins; Pregnancy specific glycoprotein
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1006/geno.1994.1395

The pregnancy-specific β1-glycoproteins (PSG) form the major group of proteins synthesized in the human placenta. There are over 30 proteins in the family, encoded by 11 genes located on chromosome 19q13.1-13.3. The genes can be divided into three subgroups based on the C-terminal exons expressed. The subgroup 1 genes have been well characterized. In this study the organization and sequence of a complete, functional, subgroup 3 gene is described. It contains the C-terminal exons, Cw, Cr, and Cs, which are expected from the transcripts characterized. Downstream from these exons are sequences homologous to the C-termini of the subgroup 1 type genes. This demonstrates that the subgroup 1, 2, and 3 genes are related via insertions/deletions. Comparison of the C-terminal sequences of the three subgroups of genes shows that the subgroup 2 and 3 genes are more closely related than, and are distinct from, the subgroup 1 genes.