Endothelial cell infection in vivo by equine infectious anaemia virus

Equine infectious anaemia virus (EIAV) infection of horses is characterized clinically by recurrent episodes of fever, thrombocytopenia and anaemia. In vivo, the only site of virus replication that has been previously demonstrated for EIAV is the tissue macrophage. In this study, in situ hybridizati...

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Bibliographic Details
Published inJournal of general virology Vol. 80; no. 9; pp. 2393 - 2397
Main Authors Oaks, J.L, Ulbarri, C, Crawford, T.B
Format Journal Article
LanguageEnglish
Published England Soc General Microbiol 01.09.1999
Subjects
Animals
Antigens, Viral - analysis
DNA, Viral - analysis
endothelium
Endothelium, Vascular - virology
Equine Infectious Anemia - virology
Equine infectious anemia virus
Horses
Infectious Anemia Virus, Equine - pathogenicity
Rabbits
Thrombocytopenia - etiology
Virulence
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Summary:Equine infectious anaemia virus (EIAV) infection of horses is characterized clinically by recurrent episodes of fever, thrombocytopenia and anaemia. In vivo, the only site of virus replication that has been previously demonstrated for EIAV is the tissue macrophage. In this study, in situ hybridization for EIAV was combined with immunohistochemistry for cell-type-specific markers to identify infected endothelial cells. EIAV-infected endothelial cells and macrophages were detected in horses infected with either virulent wild-type or with weakly virulent tissue culture-adapted strains of EIAV. The role of endothelial cell infection in the pathogenesis of EIAV remains undefined, but could contribute to the development of thrombocytopenia. However, endothelial cell infection does not appear to be a determinant of virulence for EIAV.
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ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-80-9-2393