Healthy mitochondria inhibit the metastatic melanoma in lungs

Tumor mitochondria alter their functions to reprogram cell metabolism and then allow tumor cells to rapidly proliferate in the hypoxic and acidic microenvironment. However, roles of normal mitochondria played in tumor progression are still unclear. Here we investigate the normal mitochondrial effect...

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Bibliographic Details
Published inInternational journal of biological sciences Vol. 15; no. 12; pp. 2707 - 2718
Main Authors Fu, Ailing, Hou, Yixue, Yu, Zhenyao, Zhao, Zizhen, Liu, Zesheng
Format Journal Article
LanguageEnglish
Published Australia Ivyspring International Publisher Pty Ltd 01.01.2019
Ivyspring International Publisher
Subjects
Animal models
Anticancer properties
Apoptosis
Cell proliferation
Glycolysis
Hypoxia
Lungs
Melanoma
Metabolism
Metastases
Metastasis
Microenvironments
Mitochondria
Mitochondrial DNA
Necrosis
Research Paper
Skin cancer
Survival
Tumor cells
Tumors
bioenergy
melanoma
isolated mitochondria
redox
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Summary:Tumor mitochondria alter their functions to reprogram cell metabolism and then allow tumor cells to rapidly proliferate in the hypoxic and acidic microenvironment. However, roles of normal mitochondria played in tumor progression are still unclear. Here we investigate the normal mitochondrial effect on abnormal metabolism of tumors, and to clarify why the mitochondria have to undergo functional changes in the tumor growth. The mitochondria isolated from healthy mouse livers were intravenously injected into melanoma model mice with lung metastasis, then the tumor growth, animal survival and associated metabolic changes were studied. The results reveal that the mitochondria significantly retard tumor growth and increase survival days of animals. The anti-tumor effect of the mitochondria is related to interfering the tumor cell metabolisms, such as reducing glycolysis and producing an oxidative intracellular environment, all of which are not suitable for tumor cell proliferation. In addition, the mitochondria increases cell apoptosis, necrosis, and mitophagy. These effects are more efficient with the mitochondria isolated from young mouse livers than those from aged mice. Our study not only provides a valuable approach to invest mitochondrial function associated with tumor growth but also offer new insight into tumor therapy through interfering the tumor cell metabolism by healthy mitochondria.
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Competing Interests: The authors have declared that no competing interest exists.
ISSN:1449-2288
1449-2288
DOI:10.7150/ijbs.38104