Stem cell therapy for human neurodegenerative disorders-how to make it work

Recent progress shows that neurons suitable for transplantation can be generated from stem cells in culture, and that the adult brain produces new neurons from its own stem cells in response to injury. These findings raise hope for the development of stem cell therapies in human neurodegenerative di...

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Bibliographic Details
Published inNature medicine Vol. 10 Suppl; no. 7; pp. S42 - S50
Main Authors Lindvall, Olle, Kokaia, Zaal, Martinez-Serrano, Alberto
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.07.2004
Subjects
Animal models
Animals
Biology
Brain
Clinical Medicine
Clinical trials
Clinical Trials as Topic
Disease
Dopamine
Humans
Huntington Disease - therapy
Klinisk medicin
Medical and Health Sciences
Medicin och hälsovetenskap
Neurodegenerative Diseases - therapy
Neurologi
Neurology
Neurons - physiology
Neurosciences
Parkinson Disease - therapy
Parkinson's disease
Stem Cell Transplantation
Stem cells
Stem Cells - physiology
Stroke - therapy
Transplants & implants
Sweden
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Summary:Recent progress shows that neurons suitable for transplantation can be generated from stem cells in culture, and that the adult brain produces new neurons from its own stem cells in response to injury. These findings raise hope for the development of stem cell therapies in human neurodegenerative disorders. Before clinical trials are initiated, we need to know much more about how to control stem cell proliferation and differentiation into specific phenotypes, induce their integration into existing neural and synaptic circuits, and optimize functional recovery in animal models closely resembling the human disease.
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ISSN:1078-8956
1471-003X
1546-170X
DOI:10.1038/nm1064