Anticancer activity of new organo-ruthenium, rhodium and iridium complexes containing the 2-(pyridine-2-yl)thiazole N,N-chelating ligand

• Published in: Journal of organometallic chemistry Vol. 695; no. 8; pp. 1119 - 1125
• Main Authors: Gras, Michaël, Therrien, Bruno, Süss-Fink, Georg, Casini, Angela, Edafe, Fabio, Dyson, Paul J.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.04.2010
• Subjects: Anticancer agents; Arene ligands; Bioorganometallic; Iridium; Rhodium; Ruthenium; Ruthenium; Iridium; Anticancer agents; Rhodium; Arene ligands; Bioorganometallic

New half-sandwich complexes of ruthenium, rhodium and iridium containing the 2-(pyridine-2-yl)thiazole N,N-chelating ligand display, despite strong interactions with DNA, only modest cytotoxicity towards human ovarian cancer cells. The dinuclear dichloro complexes [(η 6-arene) 2Ru 2(μ-Cl) 2Cl 2] and...