Anticancer activity of new organo-ruthenium, rhodium and iridium complexes containing the 2-(pyridine-2-yl)thiazole N,N-chelating ligand
New half-sandwich complexes of ruthenium, rhodium and iridium containing the 2-(pyridine-2-yl)thiazole N,N-chelating ligand display, despite strong interactions with DNA, only modest cytotoxicity towards human ovarian cancer cells. The dinuclear dichloro complexes [(η 6-arene) 2Ru 2(μ-Cl) 2Cl 2] and...
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Published in | Journal of organometallic chemistry Vol. 695; no. 8; pp. 1119 - 1125 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
15.04.2010
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Subjects | |
Online Access | Get full text |
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Summary: | New half-sandwich complexes of ruthenium, rhodium and iridium containing the 2-(pyridine-2-yl)thiazole
N,N-chelating ligand display, despite strong interactions with DNA, only modest cytotoxicity towards human ovarian cancer cells.
The dinuclear dichloro complexes [(η
6-arene)
2Ru
2(μ-Cl)
2Cl
2] and [(η
5-C
5Me
5)
2M
2(μ-Cl)
2Cl
2] react with 2-(pyridine-2-yl)thiazole (pyTz) to afford the cationic complexes [(η
6-arene)Ru(pyTz)Cl]
+ (arene
=
C
6H
6
1,
p-
i
PrC
6H
4Me
2 or C
6Me
6
3) and [(η
5-C
5Me
5)M(pyTz)Cl]
+ (M
=
Rh
4 or Ir
5), isolated as the chloride salts. The reaction of
2 and
3 with SnCl
2 leads to the dinuclear heterometallic trichlorostannyl derivatives [(η
6-
p-
i
PrC
6H
4Me)Ru(pyTz)(SnCl
3)]
+ (
6) and [(η
6-C
6Me
6)Ru(pyTz)(SnCl
3)]
+ (
7), respectively, also isolated as the chloride salts. The molecular structures of
4,
5 and
7 have been established by single-crystal X-ray structure analyses of the corresponding hexafluorophosphate salts. The
in vitro anticancer activities of the metal complexes on human ovarian cancer cell lines A2780 and A2780cisR (cisplatin-resistant), as well as their interactions with plasmid DNA and the model protein ubiquitin, have been investigated. |
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ISSN: | 0022-328X 1872-8561 |
DOI: | 10.1016/j.jorganchem.2010.01.020 |