Homing Receptors on Human and Rodent Lymphocytes—Evidence for a Conserved Carbohydrate-Binding Specificity

Lymphocyte recirculation begins with the attachment of circulating cells to the structurally distinctive postcapillary venules of lymphoid organs termed high-endothelial venules (HEVs). In both rodents and humans, the attachment of lymphocytes to the HEVs of peripheral lymph nodes (PNs) on the one h...

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Bibliographic Details
Published inBlood Vol. 70; no. 6; pp. 1842 - 1850
Main Authors Stoolman, L.M., Yednock, T.A., Rosen, S.D.
Format Journal Article
LanguageEnglish
Published Washington, DC Elsevier Inc 01.12.1987
The Americain Society of Hematology
Subjects
Animals
Biological and medical sciences
Carbohydrate Metabolism
Cations, Divalent
Cell Adhesion
Endothelium, Vascular - physiology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Glycoconjugates - physiology
Humans
Immunobiology
In Vitro Techniques
Lymph Nodes
Lymphocytes - physiology
Lymphoid organs: ontogeny, organization, homing phenomenon
Mannosephosphates - metabolism
Rats
Receptors, Cell Surface - physiology
Receptors, Immunologic - physiology
Receptors, Lymphocyte Homing
Species Specificity
Human
Lymph node
Rat
Biological evolution
Rodentia
Gut
Recirculation
Lymphoid tissue
Venule
Vertebrata
Mammalia
Lymphoid organ
Animal
Lymphocyte
Biological receptor
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Summary:Lymphocyte recirculation begins with the attachment of circulating cells to the structurally distinctive postcapillary venules of lymphoid organs termed high-endothelial venules (HEVs). In both rodents and humans, the attachment of lymphocytes to the HEVs of peripheral lymph nodes (PNs) on the one hand and gut-associated lymphoid tissues (GALTs) on the other appears to involve discrete adhesive structures on the surfaces of the interacting cells. In rodents, we previously showed that a carbohydrate-binding receptor at the lymphocyte surface participates in the attachment to the HEV of peripheral nodes. The studies reported herein document the involvement of a similar receptor in the selective attachment of human peripheral blood lymphocytes to the HEVs of PNs. We argue that the close functional relationship between the human and rodent receptors indicates that this component of the adhesive interaction has been conserved through evolution.
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ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V70.6.1842.1842