The Newcastle Pediatric Mitochondrial Disease Scale: translation and cultural adaptation for use in Brazil

• Published in: Arquivos de neuro-psiquiatria Vol. 74; no. 11; pp. 909 - 913
• Main Authors: Campolina-Sampaio, Gabriela Palhares, Lasmar, Laura Maria de Lima Belizário Facury, Ribeiro, Beatriz Silva Vilela, Giannetti, Juliana Gurgel
• Format: Journal Article
• Language: English
• Published: Brazil Academia Brasileira de Neurologia - ABNEURO 01.11.2016; Academia Brasileira de Neurologia (ABNEURO)
• Subjects: Adolescent; Brazil; Child; Child, Preschool; Cross-Cultural Comparison; Cross-Sectional Studies; Disease Progression; Female; Humans; Language; Leigh disease; Leigh Disease - physiopathology; Male; Mitochondrial Diseases - physiopathology; mitochondrial diseases, mitochondrial myopathies; mitochondrial encephalomyopathies; Mitochondrial Encephalomyopathies - physiopathology; Mitochondrial Myopathies - physiopathology; NEUROSCIENCES; Newcastle disease; PSYCHIATRY; Reproducibility of Results; Surveys and Questionnaires; Translations; Brazil; mitochondrial diseases, mitochondrial myopathies; Newcastle disease; doença de Newcastle; mitochondrial encephalomyopathies; Leigh disease; miopatias mitocondriais; encefalomiopatias mitocondriais; doenças mitocondriais; doença de Leigh
• ISSN: 0004-282X; 1678-4227; 1678-4227; 0004-282X
• DOI: 10.1590/0004-282X20160137

The aim of this study was to translate and adapt the Newcastle Paediatric Mitochondrial Disease Scale (NPMDS) to Portuguese for use in Brazil. The scale was applied in 20 pediatric patients with mitochondrial disease, in three groups: myopathy (n = 4); Leigh syndrome (n = 8); and encephalomyopathy (n = 8). Scores were obtained for the various dimensions of the NPMDS, and comparisons were drawn between the groups. There was a statistically significant difference between the myopathy group and the Leigh syndrome group (p = 0.0085), as well as between the myopathy and encephalomyopathy groups (p = 0.01). The translation of the NPMDS, and its adaptation to the socioeconomic and cultural conditions in Brazil, make the NPMDS score useful as an additional parameter in the evaluation and monitoring of pediatric patients with MD in Brazil.