Preparation, characterization, and optimization of pancreas-targeted 5-Fu loaded magnetic bovine serum albumin microspheres

• Published in: Journal of drug targeting Vol. 15; no. 2; pp. 140 - 145
• Main Authors: Jia, Wen Juan, Liu, Jian Gang, Zhang, Yang De, Wang, Ji Wei, Wang, Jun, Sun, Cheng Yi, Pan, Yi Feng, Yu, Chao, Li, Guo Zheng, Zhang, Heng, Gou, Ma Ling, Tu, Ming Jing, Qian, Zhi Yong
• Format: Journal Article
• Language: English
• Published: Abington Informa UK Ltd 01.01.2007; Taylor & Francis
• Subjects: 5-fluorouracil; Animals; Biological and medical sciences; Bovine serum albumin; Cattle; Chromatography, High Pressure Liquid; Fluorouracil - administration & dosage; General pharmacology; magnetic microspheres; Magnetics; Medical sciences; Microspheres; Pancreas - metabolism; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; poly(ethylene glycol); Serum Albumin, Bovine - agonists; Antineoplastic agent; magnetic microspheres; Ox; Optimization; Characterization; Ethylene oxide polymer; Target; Magnetic; poly(ethylene glycol); Microparticle; Pancreas; Ungulata; Fluorouracil; Bovine serum albumin; Microsphere; Pharmaceutical technology; Enzyme; Fluoropyrimidine derivatives; Transferases; Enzyme inhibitor; Serum albumin; Thymidylate synthase; 5-fluorouracil; Vertebrata; Mammalia; Antimetabolic; Methyltransferases; Animal; Preparation; Pyrimidine derivatives; Artiodactyla
• ISSN: 1061-186X; 1029-2330
• DOI: 10.1080/10611860601149393

The magnetic bovine serum albumin (BSA) microspheres (MS) were prepared by emulsification/solidification method. In this experiment, two kinds of magnetic MS, e.g. BSA MS and PEG-incorporated BSA microspheres (PMS) were prepared. The obtained MS were characterized by Malvern laser particle sizer and scanning electron microscopy (SEM). The obtained MS were spherical and about 1.3 μm in size. The magnetic responsivity and in vitro release behavior of these MS were studied in detail. The in vivo distribution and targeting delivery of 5-fluorouracil (5-Fu) magnetic MS after artery administration were studied in rat. The results showed that PMS could efficiently delivery 5-Fu to the targeted site compared with BSA MS without PEG MS and free drug.