Effects of probiotics on selected anthropometrics and biochemical measures in overweight or obese Saudi subjects: a double-blind, placebo-controlled, randomised clinical trial

• Published in: Public health nutrition Vol. 27; no. 1; p. e225
• Main Authors: AlMalki, Samira M, Alfawaz, Hanan A, Binmoammar, Turki A, AlBahlei, Saleh F, Al Bakr, Luluah M, Alzahrani, Ahmed M, Alshammari, Salem S, Hussain, Syed Danish, Sabico, Shaun, Al-Daghri, Nasser M
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 06.11.2024
• Subjects: Adult; Adults; Anthropometry; Anti-obesity; Bifidobacterium; Biochemistry; Biomarkers; Blindness; Blood Glucose - analysis; Blood Glucose - metabolism; Body Mass Index; Body weight; Cholesterol; Chronic illnesses; Clinical trials; Diabetes; Diet; Dietary intake; Dietary supplements; Disease prevention; Double-Blind Method; Energy Intake; Evaluation; Exercise; Female; Gender differences; Glycemic Index; Health care; Hormone replacement therapy; Humans; Interventions; Lactobacillus; Lipids; Low density lipoprotein; Male; Medical research; Microbiota; Middle Aged; Multi-strain probiotics; Nutrition research; Obesity; Obesity - blood; Obesity - therapy; Occupational health; Overweight; Overweight - blood; Overweight - therapy; Placebo effect; Placebos; Probiotic supplementations; Probiotics; Probiotics - administration & dosage; Probiotics - therapeutic use; Questionnaires; Research Paper; Saudi Arabia; Statistical analysis; Weight control; Weight reduction; Womens health; Young Adult; Saudi Arabia; Malaysia; Anti-obesity; Probiotic supplementations; Multi-strain probiotics; Weight reduction
• ISSN: 1368-9800; 1475-2727; 1475-2727
• DOI: 10.1017/S1368980024002003

This study aimed to assess the effects of multi-strain probiotics on anthropometric and biochemical measures in Saudi adults with overweight or obesity. Single-centre, double-blind, placebo-controlled, randomised clinical trial. Occupational Health Clinics at King Saud University Medical City, Riyadh, Saudi Arabia. Ninety-three Saudi participants with overweight or obesity were randomly assigned to receive twice-daily doses of either placebo ( 49) or 30 × 10 CFU/g of HEXBIO® containing three and three species ( 44) in a double-blind manner over a 12-week period, respectively. Both groups adhered to a hypoenergetic diet. Anthropometric measurements, glycaemic indices and lipid profiles were evaluated at baseline and post-intervention. Following the 12-week intervention, no statistically significant differences were found in all between the probiotic group and placebo group comparisons, except for fat intake, where the group*time interaction showed a significant decrease in favour of the probiotic group ( = 0·02). However, significant within-group reductions were observed in the probiotic group: body weight (-0·9 kg, = 0·02), HC (-1·5 cm, = 0·002), energy intake (-387·3 kcal/d, = 0·002), fasting glucose (-0·7, = 0·002) and LDL-cholesterol (-0·7, = 0·02). Consumption of multi-strain probiotic supplementation over 12 weeks significantly decreased fat intake in Saudi adults with overweight or obesity, with the probiotic group highlighting improved anthropometric and biochemical parameters. Further research is needed to evaluate the long-term clinical significance of this dietary practice and whether it has a meaningful impact on overall health beyond the placebo effect.