Recent progress in transition-metal-catalyzed enantioselective indole functionalizations

Numerous efficient synthetic methods for enantioselective indole functionalizations have emerged in recent years. This review summarizes the major achievements in the transition-metal-catalyzed enantioselective indole functionalization reactions since 2010 and focuses on C-C bond formation processes...

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Published inOrganic & biomolecular chemistry Vol. 15; no. 17; pp. 355 - 3567
Main Authors Chen, Jing-Biao, Jia, Yi-Xia
Format Journal Article
LanguageEnglish
Published England 03.05.2017
Subjects
Alkylation
Catalysis
Indoles - chemistry
Stereoisomerism
Transition Elements - chemistry
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Summary:Numerous efficient synthetic methods for enantioselective indole functionalizations have emerged in recent years. This review summarizes the major achievements in the transition-metal-catalyzed enantioselective indole functionalization reactions since 2010 and focuses on C-C bond formation processes, including alkylations, arylations, cycloaddition reactions, and other reactions. It intends to give a compendious overview of the significant progress achieved in this area. Recent progress on the transition-metal-catalyzed enantioselective functionalization reaction of indoles is reviewed, which is mainly focused on asymmetric indole alkylations, arylations, cycloaddition reactions, and other reactions.
Bibliography:Jing-Biao Chen was born in 1994 and is currently a candidate for his bachelors degree at Zhejiang University of Technology. In 2013, he began his undergraduate studies under the supervision of Prof. Yi-Xia Jia, and has been involved in the development of asymmetric Diels-Alder reactions and enantioselective dearomative arylation of naphthalene derivatives.
Yi-Xia Jia received his B.S. degree in chemistry from Zhejiang University of Technology in 1998 and PhD in organic chemistry from Nankai University in 2006 under the supervision of Prof. Qi-Lin Zhou. After about three years of postdoctoral fellowship with Prof. E. Peter Kündig at Geneva University in Switzerland, he returned to Zhejiang University of Technology and has worked as a principal investigator since 2009.
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ISSN:1477-0520
1477-0539
1477-0539
DOI:10.1039/c7ob00413c