Preparation of microcapsules with self-microemulsifying core by a vibrating nozzle method

Incorporation of drugs in self-microemulsifying systems (SMES) offers several advantages for their delivery, the main one being faster drug dissolution and absorption. Formulation of SMES in solid dosage forms can be difficult and, to date, most SMES are applied in liquid dosage form or soft gelatin...

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Bibliographic Details
Published inJournal of microencapsulation Vol. 24; no. 1; pp. 72 - 81
Main Authors Homar, Miha, Šuligoj, Daša, Gašperlin, Mirjana
Format Journal Article
LanguageEnglish
Published Colchester Informa UK Ltd 2007
Taylor & Francis
Informa
Subjects
Biological and medical sciences
Capsules - isolation & purification
Drug Compounding - methods
Drug Delivery Systems
Emulsions
General pharmacology
ketoprofen
Ketoprofen - administration & dosage
Medical sciences
microcapsules
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Self-microemulsifying systems
vibrating noozle
Vibration
Prostaglandin-endoperoxide synthase
Self-microemulsifying systems
vibrating noozle
Pharmaceutical technology
Enzyme
Microcapsule
Enzyme inhibitor
Ketoprofen
Non steroidal antiinflammatory agent
Preparation
Arylpropionic acid derivatives
Microparticle
microcapsules
Oxidoreductases
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Summary:Incorporation of drugs in self-microemulsifying systems (SMES) offers several advantages for their delivery, the main one being faster drug dissolution and absorption. Formulation of SMES in solid dosage forms can be difficult and, to date, most SMES are applied in liquid dosage form or soft gelatin capsules. This study has explored the incorporation of SMES in microcapsules, which could then be used for formulation of solid dosage forms. An Inotech IE-50 R encapsulator equipped with a concentric nozzle was used to produce alginate microcapsules with a self-microemulsifying core. Retention of the core phase was improved by optimization of encapsulator parameters and modification of the shell forming phase and hardening solution. The mean encapsulation efficiency of final batches was more than 87%, which resulted in 0.07% drug loading. It was demonstrated that production of microcapsules with a self-microemulsifying core is possible and that the process is stable and reproducible.
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ISSN:0265-2048
1464-5246
DOI:10.1080/02652040601058525