Impact of HLA on the Underlying Primary Diseases in Turkish Patients with End-Stage Renal Disease

• Published in: Renal failure Vol. 31; no. 1; pp. 44 - 49
• Main Authors: Karahan, Gonca Emel, Seyhun, Yalcin, Oguz, Fatma Savran, Kekik, Cigdem, Onal, Ayse Emel, Yazici, Halil, Turkmen, Aydin, Aydin, Ali Emin, Sever, Mehmet Sukru, Eldegez, Ulug, Carin, Mahmut Nezih
• Format: Journal Article
• Language: English
• Published: Colchester Informa UK Ltd 2009; Taylor & Francis
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Case-Control Studies; Child; Child, Preschool; Cohort Studies; disease-association; end-stage renal disease; Female; Gene Frequency; Histocompatibility Testing; HLA; HLA Antigens - genetics; Humans; Kidney Failure, Chronic - epidemiology; Kidney Failure, Chronic - genetics; Kidney Failure, Chronic - surgery; Kidney Transplantation - statistics & numerical data; Linkage Disequilibrium; Major Histocompatibility Complex - genetics; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; primary diseases; Renal failure; Risk Factors; Turkey; Waiting Lists; Young Adult; Asia; Turkey; Kidney disease; Human; HLA-System; Nephrology; Urinary system disease; Chronic renal failure; Disease; primary diseases; Major histocompatibility system; disease-association; Terminal stage; end-stage renal disease; Association; Renal failure; Primary; Anesthesia; HLA; Resuscitation
• ISSN: 0886-022X; 1525-6049
• DOI: 10.1080/08860220802546297

The number of patients with end stage renal disease (ESRD) is increasing faster than the number of renal transplantations performed per year worldwide. Of the primary diseases leading to ESRD, diabetic nephropathy is the leading cause. The purpose of the present study is to investigate the association of HLA with the primary diseases leading to ESRD in Turkish patients. A total of 3230 individuals comprising 587 ESRD patients and 2643 healthy controls were enrolled into the study. Class I HLA-A, -B typing was performed by CDC method, while class II HLA-DRB1 typing was performed by low resolution PCR-SSP. We found a significant negative association between almost all A locus antigens and primary disease groups classified as chronic glomerulonephritis and hypertensive nephrosclerosis (p < 0.05). HLA-B58 and HLA-DRB1*03 significantly correlated with amyloidosis and diabetic nephropathy, respectively. Determination of HLAs as risk factors for primary diseases leading to ESRD might be beneficial in preventing progression to ESRD and recurrence of the primary disease post-transplantation.