LncRNA ZEB2-AS1 promotes pancreatic cancer cell growth and invasion through regulating the miR-204/HMGB1 axis

Recently, lncRNA ZEB2-AS1 was identified as a lncRNA that promoted cancer progression. However, the biological function and the underlying mechanism of ZEB2-AS1 in pancreatic cancer had not been reported. In the current study, we revealed that the expression level of ZEB2-AS1 was elevated in pancrea...

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Bibliographic Details
Published inInternational journal of biological macromolecules Vol. 116; pp. 545 - 551
Main Authors Gao, Hai, Gong, Nana, Ma, Zebin, Miao, Xiaobo, Chen, Jinchun, Cao, Yan, Zhang, Gong
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.09.2018
Subjects
HMGB1
LncRNA ZEB2-AS1
miR-204
Pancreatic cancer
miR-204
LncRNA ZEB2-AS1
HMGB1
Pancreatic cancer
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Summary:Recently, lncRNA ZEB2-AS1 was identified as a lncRNA that promoted cancer progression. However, the biological function and the underlying mechanism of ZEB2-AS1 in pancreatic cancer had not been reported. In the current study, we revealed that the expression level of ZEB2-AS1 was elevated in pancreatic cancer cell lines and tissues. ZEB2-AS1 inhibition decreased cell growth and invasion in pancreatic cancer. Mechanismly, ZEB2-AS1 exerted as a ceRNA and negatively regulated miR-204 expression. In addition, HMGB1 was identified as a down-stream target of miR-204. The miR-204/HMGB1 axis mediated ZEB2-AS1's effect on pancreatic cancer. Our findings revealed that lncRNA ZEB2-AS1 may be a candidate prognostic biomarker and a target for new therapies in pancreatic cancer patients.
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ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2018.05.044