Prior SARS‐CoV‐2 infection balances immune responses triggered by four EMA‐approved COVID‐19 vaccines: An observational study

• Published in: Clinical and translational medicine Vol. 12; no. 5; pp. e869 - n/a
• Main Authors: Lozano‐Rodríguez, Roberto, Terrón‐Arcos, Verónica, Montalbán‐Hernández, Karla, Casalvilla‐Dueñas, José Carlos, Bergón‐Gutierrez, Marta, Pascual‐Iglesias, Alejandro, Quiroga, Jaime Valentín, Aguirre, Luis A., Pérez de Diego, Rebeca, Vela‐Olmo, Carmen, López‐Morejón, Lissette, Martín‐Quirós, Alejandro, del Balzo‐Castillo, Álvaro, Peinado‐Quesada, María A., García‐Garrido, Miguel A., Gómez‐Lage, Laura, Herrero‐Benito, Carmen, Llorente‐Fernández, Irene, Martín‐Miguel, Gema, Torrejón, Margarita, Cubillos‐Zapata, Carolina, del Fresno, Carlos, Avendaño‐Ortiz, José, López‐Collazo, Eduardo
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.05.2022; John Wiley and Sons Inc; Wiley
• Subjects: Antibodies; Coronaviruses; COVID-19 vaccines; Disease transmission; Immunization; Infections; Letter to the Editor; Severe acute respiratory syndrome coronavirus 2; Spain
• ISSN: 2001-1326; 2001-1326
• DOI: 10.1002/ctm2.869

Other authors have reported that in natural infection anti-Spike RBD IgA antibodies showed to be the major responsible of the neutralizing ability in early stages.2 Regarding the cellular response, CD4+ but not CD8+ T-cell activities against SARS-CoV-2 spike peptide pool (Supporting information Figure S2A) remained high at late-time points in naïve individuals immunized with the mRNA-type vaccines (Figures 2C and Supporting information Figure S2B). [...]when comparing humoral and cellular responses between naïve and COVID-19-recovered subjects, we found higher anti-spike RBD IgG and neutralizing antibodies levels in recovered individuals, but no differences in the cellular CD4+ T-cell response were found (Figure 4). Several studies performed in Spain confirm the impact of ratcheting up SARS-CoV-2 vaccination has had on declining COVID-19 hospitalizations and lethality rates, even though a lack of efficiency reducing the transmission rate was observed.3,4 Additionally, these high ranks of vaccination have supposed a reduction in the use of medical resources with a high social returns.5 Nevertheless, a comparison between the differential immune responses triggered by each vaccine is still lacking.