Antitumor effect of new local hyperthermia using dextran magnetite complex in hamster tongue carcinoma

• Published in: Oral diseases Vol. 9; no. 4; pp. 218 - 223
• Main Authors: Wada, S, Tazawa, K, Furuta, I, Nagae, H
• Format: Journal Article
• Language: English
• Published: Oxford, UK Munksgaard International Publishers 01.07.2003; Blackwell
• Subjects: 9,10-Dimethyl-1,2-benzanthracene; alternating current magnetic field; Animals; Biological and medical sciences; Body Temperature - physiology; Carcinogens; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - therapy; Cricetinae; dextran magnetite complex; Ent. Stomatology; hyperthermia; Hyperthermia, Induced - methods; Inductive heating; Iron-Dextran Complex - therapeutic use; Magnetics - instrumentation; Magnetics - therapeutic use; Male; Medical sciences; Mesocricetus; oral cancer therapy; Otorhinolaryngology. Stomatology; Pharmacology. Drug treatments; Survival Rate; Thermometers; Time Factors; Tongue Neoplasms - pathology; Tongue Neoplasms - therapy; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Squamous cell carcinoma; Tongue; Stomatology; Rodentia; Malignant tumor; Experimental study; Complexes; Premises; Dextran; Vertebrata; Chemotherapy; Mammalia; Magnetite; Treatment; Blood substitute; Animal; Oral cavity disease; Biological effect; Hyperthermia; Hamster
• ISSN: 1354-523X; 1601-0825
• DOI: 10.1034/j.1601-0825.2003.02839.x

OBJECTIVE: This study was performed to clarify the usefulness of Dextran magnetite (DM) for the oral cancer hyperthermia. METHODS: Tumors were induced in golden hamster tongue by 9,10‐dimethyl 1‐1,2‐benzanthracene (DMBA) application. DM suspension was locally injected into the tumor‐bearing tongue and tongues were heated up to 43.0–45.0°C, by AC magnetic field of 500 kHz. RESULTS: The average time taken for the temperature to rise to 43.0°C or above was 162 s (n = 17) at the margin of the tumor and 420 s (n = 17) at the center of the tumor. According to the tumor volume, the time required for an increase in the central temperature of tumor to 43.0°C tended to be prolonged. Both temperatures could be maintained at approximately 43.0–45.0°C for 30 min. The inhibition of the growth of tongue carcinoma in the four‐time heating group was significantly greater than in the control group (P < 0.01). Moreover, the survival rate was significantly higher in the heated groups than in the control group (P < 0.01). Histological examination revealed a brown uniform DM accumulation at the stroma in the margin of the tumors. Many of tumor cells disappeared at the site adjacent to this accumulation. CONCLUSION: These results strongly suggest the usefulness of this local hyperthermic system in the oral region that is accessible to this treatment.