Controlled release of bovine serum albumin using MPEG-PCL diblock copolymers as implantable protein carriers

• Published in: Journal of applied polymer science Vol. 102; no. 2; pp. 1561 - 1567
• Main Authors: Kim, Moon Suk, Seo, Kwang Su, Hyun, Hoon, Khang, Gilson, Cho, Sun Hang, Lee, Hai Bang
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.10.2006; Wiley
• Subjects: Applied sciences; Biological and medical sciences; bovine serum albumin; drug carrier; Exact sciences and technology; General pharmacology; implantable wafer; Medical sciences; MPEG-PCL; Organic polymers; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physicochemistry of polymers; Properties and characterization; Special properties (catalyst, reagent or carrier); Property composition relationship; Drug carrier; Lactone polymer; Caprolactone copolymer; Cyclic ether copolymer; MPEG-PCL; Ungulata; Release; Lactone copolymer; Bovine; Controlled release form; Pastille; Control release polymer; implantable wafer; Serum albumin; Ethylene oxide copolymer; Experimental study; Protein; Vertebrata; Mammalia; Cyclic ether polymer; Diblock copolymer; Artiodactyla; Kinetics; bovine serum albumin
• ISSN: 0021-8995; 1097-4628
• DOI: 10.1002/app.23528

MPEG–PCL diblock copolymers consisting of methoxy polyethylene glycol (MPEG) and poly(ϵ‐caprolactone) (PCL) as drug carriers were synthesized by ring‐opening polymerization. It is possible to control the balance between hydrophilic and hydrophobic by changing the MPEG and the ratio of ϵ‐CL to MPEG. Implantable wafers were easily fabricated by the direct compression method after physical mixing of diblock copolymers and bovine serum albumin–fluorescein isothiocyanate (BSA‐FITC) as a model protein drug. The BSA release from wafers prepared by MPEG–PCL diblock copolymers were higher than that from PCL with the physical blending of MPEG. The wafers prepared by a variety of MPEG–PCL diblock copolymers exhibited the controlled BSA release profiles with a dependence on MPEG–PCL diblock copolymer compositions. In addition, the changing of MPEG and PCL molecular weights within MPEG–PCL diblock copolymer controlled the initial burst of BSA. We confirmed that the diblock copolymers could be served as protein delivery carrier in implantable wafer form. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102:1561–1567, 2006