Pharmacokinetics of hydromorphone after intravenous, peroral and rectal administration to human subjects

The pharmacokinetic properties of hydromorphone in healthy young male subjects were studied after i.v., peroral, and rectal administration. After i.v. administration the following pharmacokinetic parameters were found: elimination half-life 2.36 +/- 0.5 h, hepatic extraction ratio 0.51, apparent vol...

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Bibliographic Details
Published inBiopharmaceutics & drug disposition Vol. 9; no. 2; p. 187
Main Authors Parab, P V, Ritschel, W A, Coyle, D E, Gregg, R V, Denson, D D
Format Journal Article
LanguageEnglish
Published England 01.03.1988
Subjects
Administration, Oral
Administration, Rectal
Adult
Biological Availability
Humans
Hydromorphone - administration & dosage
Hydromorphone - pharmacokinetics
Injections, Intravenous
Male
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Summary:The pharmacokinetic properties of hydromorphone in healthy young male subjects were studied after i.v., peroral, and rectal administration. After i.v. administration the following pharmacokinetic parameters were found: elimination half-life 2.36 +/- 0.5 h, hepatic extraction ratio 0.51, apparent volume of distribution 2.9 +/- 1.3 L kg-1 and volume of central compartment 0.23 +/- 0.2 L kg-1. The absolute bioavailability after peroral administration was 50.7 +/- 29.8 per cent, and that after rectal administration was 33 +/- 22 per cent.
ISSN:0142-2782
DOI:10.1002/bod.2510090207