Clinical Pattern of Celiac Disease Is Still Changing

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 45; no. 5; pp. 611 - 614
• Main Authors: Garampazzi, Andrea, Rapa, Anna, Mura, Serena, Capelli, Antonella, Valori, Anna, Boldorini, Renzo, Oderda, Giuseppina
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins, Inc 01.11.2007; Lippincott
• Subjects: Abdominal Pain - epidemiology; Adolescent; Age Factors; Age of Onset; Atypical forms; Biological and medical sciences; Body Height; Breast Feeding - epidemiology; Celiac disease; Celiac Disease - diet therapy; Celiac Disease - epidemiology; Child; Child, Preschool; Clinical presentation; Comorbidity; Diarrhea - epidemiology; Endoscopy, Digestive System; Esophagitis; Esophagitis - epidemiology; Esophagus; Failure to Thrive; Female; Gastritis; Gastritis - epidemiology; Gastroenterology. Liver. Pancreas. Abdomen; Glutens - administration & dosage; Health Surveys; Humans; Infant; Irritable Mood; Italy - epidemiology; Male; Medical sciences; Other diseases. Semiology; Prevalence; Silent forms; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Typical forms; Vomiting - epidemiology; Italy; Human; Immunopathology; Prevalence; Atypical forms-Celiac disease-Clinical presentation-Esophagitis-Gastritis-Silent forms-Typical forms; Esophageal disease; Clinical form; Esophagitis; Coeliac disease; Epidemiology; Gastritis; Symptomatology; Intestinal malabsorption; Digestive diseases; Intestinal disease; Atypical; Diagnosis; Child; Gastric disease
• ISSN: 0277-2116; 1536-4801
• DOI: 10.1097/MPG.0b013e31814c3d79

ABSTRACT The clinical presentation of celiac disease in children changed in the last decades of the 20th century. To ascertain whether changes are still in progress, we analyzed symptoms at presentation and age at diagnosis in 307 children receiving diagnoses of celiac disease for the past 20 years. The prevalence of typical forms of celiac disease decreased in the past decade, particularly in the past 5 years (from 76% in 1987–1990 to 44%, P < 0.0001). Age at diagnosis (5.9 y, P = 0.01) and silent forms (10.6%, P = 0.003) have significantly increased in the past 5 years. Histological examination showed decreased subtotal and increased partial villous atrophy prevalence (P = 0.02).