Atomic Force Microscopy as a Tool for Biomedical and Biotechnological Studies

• Published in: Artificial organs Vol. 27; no. 5; pp. 447 - 451
• Main Authors: Cidade, Geraldo Antônio Guerrera, Costa, Lilian Terezinha, Weissmüller, Gilberto, Da Silva Neto, Antônio José, Roberty, Nilson Costa, De Moraes, Marta Bueno, Prazeres, Gilza Maria Piedade, Hill, Carlos Eduardo Marques, Ribeiro, Simone Jesus Machado, De Souza, Gutierre Guarino Bastos, Da Silva Pinto Teixeira, Luciano, Da Costa Monçores, Marlos, Bisch, Paulo Mascarello
• Format: Journal Article
• Language: English
• Published: Oxford, UK and Malden, USA Blackwell Science Inc 01.05.2003
• Subjects: Atomic force microscopy; Biological samples; Biomedical Technology; Cell Biology - instrumentation; Force spectroscopy; Image Processing, Computer-Assisted - instrumentation; Image Processing, Computer-Assisted - methods; Image restoration; Imaging, Three-Dimensional; Microscopy, Atomic Force - methods; Surface Properties; Tip functionalization
• ISSN: 0160-564X; 1525-1594
• DOI: 10.1046/j.1525-1594.2003.07237.x

: This work presents different applications in progress with the aid of the atomic force microscopy (AFM) technique for biomedical and biotechnological applications, comprising both the acquisition of three‐dimensional images and spectroscopic force measurements, in the following systems: first, low‐density lipoprotein (LDL)–glycosaminoglycans; second, lectins‐polysaccharides; third, mycobacterium leprae cellular wall and Vesicular Stomatites Virus (VSV) with fibronectin laminin, and lipidic membranes; fourth, DNA—complex; and fifth, actin, as well as the development of surface functionalizing protocols and image restoration by means of mathematical techniques.