Multiple Basal Cell Carcinomas in Xeroderma Pigmentosum Treated with Imiquimod 5% Cream

• Published in: Pediatric dermatology Vol. 25; no. 4; pp. 488 - 491
• Main Authors: MALHOTRA, AMIT KUMAR, GUPTA, SOMESH, KHAITAN, BINOD K., VERMA, KAUSHAL K.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2008; Blackwell
• Subjects: Adolescent; Aminoquinolines - administration & dosage; Antineoplastic Agents - administration & dosage; Biological and medical sciences; Carcinoma, Basal Cell - complications; Carcinoma, Basal Cell - drug therapy; Dermatology; Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue; Humans; Male; Medical sciences; Ointments; Skin involvement in other diseases. Miscellaneous. General aspects; Skin Neoplasms - complications; Skin Neoplasms - drug therapy; Tumors of the skin and soft tissue. Premalignant lesions; Xeroderma Pigmentosum - complications; Xeroderma Pigmentosum - drug therapy; Photosensitivity; Pediatrics; Skin disease; Pigmentation disorder; Basal cell carcinoma; Multiple; Dermatology; Imiquimod; Cream; Xeroderma pigmentosum; Malignant tumor; Genetic disease; Immunomodulator; Photodermatosis; Treatment; Cancer
• ISSN: 0736-8046; 1525-1470
• DOI: 10.1111/j.1525-1470.2008.00727.x

:  We report successful treatment of multiple basal cell carcinomas with imiquimod 5% cream in a 16‐year‐old boy with xeroderma pigmentosum and review the possibility of prophylactic role of imiquimod in the disease. Imiquimod cream was applied uniformly over all the basal cell carcinoma lesions and background pigmented skin, once at bedtime on every alternate day for 12 weeks. Besides the basal cell carcinomas, the background hyperpigmentation and keratotic papules also cleared, and the skin texture improved. The lesions did not recur at the treated sites during the follow up of 1 year.