FoxO4 is the main forkhead transcriptional factor localized in the gastrointestinal tracts of pigs

• Published in: Journal of Zhejiang University. B. Science Vol. 8; no. 1; pp. 39 - 44
• Main Authors: Zhou, Zhen-qi, Wang, Tian, Pan, Ling-mei, Huang, Rui-hua, Shi, Fang-xiong
• Format: Journal Article
• Language: English
• Published: China College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China 2007; Zhejiang University Press
• Subjects: Animals; Bioengineering; Female; Forkhead Transcription Factors - metabolism; Fox蛋白; Gastrointestinal Tract - metabolism; Immunohistochemistry; Male; Sus scrofa - metabolism; Tissue Distribution; 免疫组织化学定位; 叉头螺旋转录因子; 胃肠道; Immunohistochemistry; Forkhead; FoxO; Gastrointestinal tract; Swine
• ISSN: 1673-1581; 1862-1783
• DOI: 10.1631/jzus.2007.b0039

Forkhead box （Fox） proteins play critical roles in the regulation of differentiation, proliferation, immunity and aging of cells. Most studies on Fox proteins are limited to cultured cells and rodent. The aim of the current study is to detect by immunohistrochemistry whether FoxO1, FoxO3a and FoxO4 proteins are localized in the stomach and intestine of the pig. The results showed that FoxO4 exists in the mucosa in all parts of the stomach and intestine; FoxO3a exists mainly in the lamina propria and muscularis of some parts. However, FoxOl is not detectable in all parts of the stomach and intestine. Collectively, the results of the present study indicate that there exists a distinct expression pattern of Fox proteins, and that FoxO4 is a primary forkhead transcriptional factor localized in the gastrointestinal tracts of the pig.