Developmental Gene Expression of Trypsinogen and Lipase in Human Fetal Pancreas

BACKGROUND:Very few studies have been reported on the expression of human pancreatic genes during fetal development. We have shown very low lipase immunoreactivity compared with elevated trypsinogen immunoreactivity in a previous immunohistological study of human fetal pancreas during development. M...

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Published inJournal of pediatric gastroenterology and nutrition Vol. 24; no. 1; pp. 63 - 67
Main Authors Moriscot, Christine, Renaud, Wanda, Carrère, Jacqueline, Figarella-Branger, Dominique, Figarella, Catherine, Guy-Crotte, Odette
Format Journal Article
LanguageEnglish
Published Hagerstown, MD Lippincott-Raven Publishers 01.01.1997
Lippincott
Subjects
Adult
Biological and medical sciences
Blotting, Northern
Embryonic and Fetal Development
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gene Expression
Gestational Age
Humans
Lipase - genetics
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Other diseases. Semiology
Pancreas - embryology
Pancreas - enzymology
Pregnancy
RNA, Messenger - metabolism
Trypsinogen - genetics
Human
Immunohistochemistry
Evaluation
Genetic inheritance
Enzyme
Triacylglycerol lipase
Esterases
Gene expression
Carboxylic ester hydrolases
Ethics
Fetal development
Trypsinogen
Digestive diseases
Hydrolases
Pancreas
Comparative study
Pancreatic disease
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Summary:BACKGROUND:Very few studies have been reported on the expression of human pancreatic genes during fetal development. We have shown very low lipase immunoreactivity compared with elevated trypsinogen immunoreactivity in a previous immunohistological study of human fetal pancreas during development. METHODS:The expression of these two selectively expressed genes of the exocrine pancreas, trypsinogen and lipase were investigated. The developmental profiles of the corresponding mRNA's were determined from the 13th gestational week. RESULTS:For the two genes, fetal mRNA levels throughout gestation remained significantly lower than the corresponding adult levels. No correlation was found between trypsinogen and lipase gene expression in the fetal pancreas, whereas such a correlation was present in adult pancreas. This may be explained by differences in maturity of the pancreas.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0277-2116
1536-4801
DOI:10.1097/00005176-199701000-00015