Extraction and identification of trophoblast cells circulating in peripheral blood during pregnancy

Trophoblast cells circulating in peripheral venous blood during pregnancy were extracted by differential centrifugation and identified by indirect immunofluorescence with antitrophoblast microvillus antibody. In a study where trophoblast identification was checked by blind comparison with non-pregna...

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Bibliographic Details
Published inBritish journal of obstetrics and gynaecology Vol. 89; no. 1; p. 65
Main Authors Goodfellow, C F, Taylor, P V
Format Journal Article
LanguageEnglish
Published England 01.01.1982
Subjects
Blood Cells - cytology
Centrifugation, Zonal
Female
Fluorescent Antibody Technique
Humans
Pregnancy
Trophoblasts - cytology
Trophoblasts - immunology
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Summary:Trophoblast cells circulating in peripheral venous blood during pregnancy were extracted by differential centrifugation and identified by indirect immunofluorescence with antitrophoblast microvillus antibody. In a study where trophoblast identification was checked by blind comparison with non-pregnant control subjects' trophoblast cells were detected in six out of 10 pregnant women studied.
ISSN:0306-5456
DOI:10.1111/j.1471-0528.1982.tb04638.x