Müllerian‐type carcinosarcoma arising in gastric endometriosis: Case report and review of the literature

• Published in: Clinical case reports Vol. 12; no. 3; pp. e8604 - n/a
• Main Authors: Peerenboom, Rayne, Wang, Sabrina, Morgan, Ryan, Sankary, Seth, Yassan, Lindsay, Kurnit, Katherine, Posner, Mitchell C.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.03.2024; John Wiley and Sons Inc; Wiley
• Subjects: Abdomen; Antigens; Asymptomatic; Biopsy; carcinosarcoma; Case Report; Case reports; cell transformation; Chemotherapy; Colon; Cysts; Diverticulitis; Endometriosis; Gastric cancer; gastrointestinal neoplasms; Gastrointestinal surgery; gynecologic neoplasms; Laparoscopy; Metastasis; Nausea; Obstetrics/Gynecology; Oncology; Ovarian cancer; Pain; Pathology; Pelvis; Stomach; stomach neoplasms; Surgery; cell transformation; endometriosis; carcinosarcoma; gynecologic neoplasms; gastrointestinal neoplasms; stomach neoplasms
• ISSN: 2050-0904; 2050-0904
• DOI: 10.1002/ccr3.8604

Key Clinical Message Although endometriosis is a common condition, both extrapelvic endometriosis and endometriosis associated malignancy (EAM) are rare. We describe the first reported case of a patient with Müllerian‐type carcinosarcoma arising in gastric endometriosis. Imaging findings, including (A) CT demonstrating cystic lesion emanating from the lesser curvature in the proximal stomach and (B) EUS with submucosal cystic mass measuring 10.3 cm, located 3 cm distal to gastroesophageal junction, with internal solid component; and final pathology, including (C) opened 11.0 × 7.6 × 3.8 cm cystic lesion with nodular excrescences in the gastric body near the lesser curvature, (D) areas of squamous differentiation, (E) chondrosarcomatous component, (F) solid areas composed of poorly differentiated cells, suggestive of a dedifferentiated component with readily identifiable mitotic figures, (G) background of endometriosis, and (H) carcinomatous component with patchy PAX‐8 nuclear staining.