Interproximal periodontal defect model in dogs: a pilot study

• Published in: Oral diseases Vol. 17; no. 1; pp. 26 - 32
• Main Authors: Jung, U-W, Chang, Y-Y, Um, Y-J, Kim, C-S, Cho, K-S, Choi, S-H
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2011; Wiley Subscription Services, Inc
• Subjects: Alveolar Bone Loss - complications; Alveolar Bone Loss - surgery; animal models; Animals; Bone Regeneration - physiology; Dental Cementum - physiology; Dentistry; Disease Models, Animal; Dogs; histology; Male; Maxilla; periodontal; Periodontal Diseases - complications; Periodontal Diseases - surgery; Periodontium - physiology; Periodontium - surgery; Pilot Projects; Regeneration - physiology; Root Planing; Surgical Flaps; Wound Healing - physiology; X-ray microtomography
• ISSN: 1354-523X; 1601-0825
• DOI: 10.1111/j.1601-0825.2010.01694.x

Oral Diseases (2010) 17, 26–32 Objective:  This study aimed to evaluate the validity of a surgically created interproximal periodontal defect in dogs. Materials and methods:  Surgery was performed in the interproximal area between the maxillary second and third premolars in two beagle dogs. Following an incision and reflection of the gingival flap, a 3‐mm wide and 5‐mm high defect was prepared surgically at the interproximal area. A thorough root planing was performed and the flap was coronally positioned and sutured. The contra‐lateral area was served as the control with no surgical intervention. After 8 weeks of healing, the animals were killed and the defect was analysed histometrically and radiographically. Results:  The interproximal periodontal defect resembled a naturally occurring defect and mimicked a clinical situation. After healing, the defect showed limited bone (0.89 ± 0.02 mm) and cementum regeneration (1.50 ± 0.48 mm). Conclusions:  Within the limitations of this pilot study, the interproximal periodontal defect showed limited bone and cementum regeneration. Thus, it can be considered as a standardized, reproducible defect model for testing new biomaterials.