Cobalt(III)-Catalyzed CH/NO Functionalizations: Isohypsic Access to Isoquinolines

• Published in: Chemistry : a European journal Vol. 21; no. 44; pp. 15525 - 15528
• Main Authors: Wang, Hui, Koeller, Julian, Liu, Weiping, Ackermann, Lutz
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 26.10.2015; WILEY‐VCH Verlag
• Subjects: Activation; alkyne; Alkynes; Catalysis; Chemical reactions; cobalt; CH activation; isoquinoline; N-O cleavage; Organic chemistry; Strategy; Synthesis; Terminals; CH activation; alkyne; cobalt; isoquinoline; N-O cleavage
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.201503624

CH/NO functionalizations by cobalt(III) catalysis allowed the expedient synthesis of a broad range of isoquinolines. Thus, internal and challenging terminal alkynes proved to be viable substrates for an isohypsic annulation, which was shown to proceed by a facile CH cobaltation. Versatile cobalt(III) catalysis enabled alkyne annulations in the absence of external oxidants, allowing the synthesis of a broad range of isoquinolines. The robust CH/NO functionalization strategy proceeded by facile CH activation in high yields within 15 min.