Early prediction of anthracycline induced cardiotoxicity

• Published in: Acta Paediatrica Vol. 96; no. 4; pp. 506 - 509
• Main Authors: Erkus, Bedirhan, Demirtas, Selda, Yarpuzlu, Aysegul Akbay, Can, Murat, Genc, Yasemin, Karaca, Levent
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2007; Blackwell
• Subjects: Anthracyclines; Anthracyclines - administration & dosage; Anthracyclines - adverse effects; Antibiotics, Antineoplastic - administration & dosage; Antibiotics, Antineoplastic - adverse effects; Antioxidant status; Antioxidants - metabolism; Biological and medical sciences; Brain natriuretic peptide; Cardiac troponin; Cardiotoxicity; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions - blood; Drug-Related Side Effects and Adverse Reactions - diagnostic imaging; Drug-Related Side Effects and Adverse Reactions - physiopathology; Female; General aspects; Humans; Infant; Male; Medical sciences; Natriuretic Peptide, Brain - blood; Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma - physiopathology; Predictive Value of Tests; Stroke Volume - drug effects; Stroke Volume - physiology; Troponin I - blood; Ultrasonography; Heart; Brain natriuretic peptide; Pediatrics; Anthracyclines; Toxicity; Prediction; Cardiotoxicity; Antioxidant; Antioxidant status; Troponin; Early; Anthracyclins; Cardiac troponin; Circulatory system; Predictive factor
• ISSN: 0803-5253; 1651-2227
• DOI: 10.1111/j.1651-2227.2006.00174.x

Aim: The purpose of this study is to evaluate echocardiographically determined cardiac functions with serum levels of brain natriuretic peptide (BNP), cardiac troponin I (cTnI) and total antioxidant status (TAOS) in childhood leukemia treated with chemotherapeutics containing anthracyclines. Methods: A study group of 29 patients who have been followed for acute lymphoblastic leukemia (ALL) and administered a treatment protocol containing chemotherapy of anthracyclines were included in the analysis. Levels of BNP, cTnI and TAOS were studied in serum samples of the patients. Results: We demonstrated that as the drug dosage increased, systolic ejection fraction (EF) and shortening fraction (FS) values decreased (EF r2= 0.2327, FS r2= 0.251). On the other hand, increased dosage of anthracycline therapy was associated with significant raise in plasma BNP levels (r2= 0.246) and significant decrease in serum TAOS levels (r2= 0.317) without any change in serum cTnI levels. Conclusion: Our study suggest that serum TAOS and BNP levels may be useful as an early and sensitive indicator of anthracycline induced cardiotoxicity.