Spiegelmers: Biostable Aptamers

Not from this world: Mirror‐image nucleic acids are made of L‐nucleotides instead of natural D‐nucleotides. Just like natural D‐nucleic acids, single‐stranded L‐oligonucleotides can fold into distinct 3D structures and are thus capable of tightly and specifically binding to a given target (see pictu...

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Bibliographic Details
Published inChembiochem : a European journal of chemical biology Vol. 4; no. 10; pp. 979 - 983
Main Authors Eulberg, Dirk, Klussmann, Sven
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 06.10.2003
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects
Animals
aptamers
Binding Sites
Circular Dichroism
Gene Library
Humans
Ligands
oligonucleotides
Oligonucleotides - chemistry
Oligonucleotides - metabolism
Peptides - chemistry
Peptides - metabolism
Protein Binding
RNA
RNA - chemistry
RNA - metabolism
SELEX
Signal Transduction
spiegelmers
Stereoisomerism
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Summary:Not from this world: Mirror‐image nucleic acids are made of L‐nucleotides instead of natural D‐nucleotides. Just like natural D‐nucleic acids, single‐stranded L‐oligonucleotides can fold into distinct 3D structures and are thus capable of tightly and specifically binding to a given target (see picture). As a result of their non‐natural chirality, such “spiegelmers” are not substrates for nucleases and therefore persist even in body fluids.
Bibliography:http://dx.doi.org/10.1002/cbic.200300663
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ISSN:1439-4227
1439-7633
1439-4227
DOI:10.1002/cbic.200300663