Comparison of histologic, biochemical, and mechanical properties of murine skin treated with the 1064-nm and 1320-nm Nd:YAG lasers

• Published in: Experimental dermatology Vol. 14; no. 12; pp. 876 - 882
• Main Authors: Dang, Yong-Yan, Ren, Qiu-Shi, Liu, Hua-Xu, Ma, Jing-Bo, Zhang, Jin-Sheng
• Format: Journal Article
• Language: English
• Published: Oxford, UK; Malden, USA Munksgaard International Publishers 01.12.2005; Blackwell
• Subjects: Animals; Biological and medical sciences; collagen; Collagen Type I - metabolism; Collagen Type III - metabolism; Dermatology; Elasticity; hydroxyproline; Hydroxyproline - metabolism; Lasers; Medical sciences; Mice; Mice, Inbred Strains; non-ablative treatment; Skin - metabolism; Skin - pathology; Skin - physiopathology; Skin - radiation effects; skin elasticity; Neodymium; Dermatology; Hydroxyproline; YAG laser; Rodentia; Elasticity; Mechanical properties; Biochemistry; Histology; skin elasticity; Vertebrata; Mammalia; non-ablative treatment; Mouse; Animal; Collagen; Skin; Biological effect; Comparative study
• ISSN: 0906-6705; 1600-0625
• DOI: 10.1111/j.1600-0625.2005.00371.x

:  The goal of this study was to compare the effects of the Q‐switched 1064‐nm Nd:YAG laser and the 1320‐nm Nd:YAG laser non‐ablative treatments on mouse skin in vivo. Skin elasticity measurements were carried out with a Reviscometer, and skin samples were taken for histological study, hydroxyproline content assay and estimation of collagen type I and III. By the second month after non‐ablative treatments, the 1064‐nm laser treatment resulted in an average of 25% greater improvement of skin elasticity, 6% more increase of dermal thickness, and 11% higher synthesis of hydroxyproline than the 1320‐nm laser. Collagen type III increased markedly after the 1064‐nm laser treatment whereas more collagen type I was elicited by the 1320‐nm laser. Our results demonstrated that the 1064‐nm laser was more effective than the 1320‐nm Nd:YAG laser in non‐ablative treatments, but the results needed to be confirmed in humans. It appeared that photo‐mechanic reaction could cause more collagen type III synthesis whereas the photo‐thermal effect was in favor of the formation of collagen type I.