Functionalization of biomaterial surfaces using artificial extracellular matrices

• Published in: Biomatter (Austin, TX) Vol. 2; no. 3; pp. 132 - 141
• Main Authors: Bierbaum, Susanne, Hintze, Vera, Scharnweber, Dieter
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.07.2012; Landes Bioscience
• Subjects: Adsorption; Animals; artificial extracellular matrix; Binding; bioactive coatings; Biocompatible Materials - chemistry; Biology; Bioscience; Calcium; Cancer; Cell; Cell Lineage; collagen; Collagen - chemistry; Cycle; Extracellular Matrix - metabolism; Glycoproteins - chemistry; Glycosaminoglycans - chemistry; Humans; immobilization; implants; Landes; Organogenesis; Proteins; Proteoglycans - chemistry; Special Focus Review; surface functionalization; Tissue Engineering - methods; collagen; bioactive coatings; immobilization; artificial extracellular matrix; implants; surface functionalization
• ISSN: 2159-2527; 2159-2535; 2159-2535
• DOI: 10.4161/biom.20921

Construction of biomaterials with the ability to guide cell function is a topic of high interest in biomaterial development. One approach is using components native to the ECM of the target tissue to generate in vitro a microenvironment that can also elicit specific responses in cells and tissues-an artificial ECM (aECM). The focus is on collagen as the basic material, which can be modified using a number of different glycoproteins, proteoglycans and glycosaminoglycans. Preparation, immobilization and the biochemical characteristics of such aECM are discussed, as well as the in vitro and in vivo response of cells and tissues, illustrating the potential of such matrices to direct cell fate.