Molecular differential pathology of renal cell tumours

Recent application of molecular cytogenetic techniques to the evaluation of renal cell tumours revealed four subtypes, each with a characteristic combination of genetic alterations within the chromosomal and mitochondrial DNA. The most common, nonpapillary renal cell carcinomas are characterized by...

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Bibliographic Details
Published inHistopathology Vol. 22; no. 1; p. 1
Main Author Kovacs, G
Format Journal Article
LanguageEnglish
Published England 01.01.1993
Subjects
Adenoma - classification
Adenoma - genetics
Adenoma - pathology
Carcinoma, Renal Cell - classification
Carcinoma, Renal Cell - genetics
Carcinoma, Renal Cell - pathology
Chromosome Aberrations
Female
Humans
Kidney Neoplasms - classification
Kidney Neoplasms - genetics
Kidney Neoplasms - pathology
Male
Phenotype
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Summary:Recent application of molecular cytogenetic techniques to the evaluation of renal cell tumours revealed four subtypes, each with a characteristic combination of genetic alterations within the chromosomal and mitochondrial DNA. The most common, nonpapillary renal cell carcinomas are characterized by the loss of chromosome 3p sequences, rearrangement of the chromosome 5q region and loss of the chromosome 14q sequences. Papillary renal cell tumours can be divided into two groups. Tumours with a combined trisomy of chromosomes 7 and 17 as well as loss of the Y chromosome are papillary renal cell adenomas. Tumours with additional trisomies such as trisomy 16, 20 or 12 are papillary renal cell carcinomas. Chromophobe renal cell carcinomas show a combination of allelic losses, which do not occur in other types of renal tumours. In addition, they have a rearrangement in the mitochondrial DNA. Renal oncocytomas are benign tumours marked by normal or abnormal karyotypes with balanced or unbalanced translocations and an altered restriction pattern of the mitochondrial DNA. Although the major cytological characteristics of renal cell tumours, such as clear, granular, chromophobe and oncocytic cell phenotypes correspond to nonpapillary, papillary and chromophobe renal cell carcinomas and renal oncocytomas, there are many cases with overlapping phenotype. Therefore, a classification of renal cell tumours based on specific genetic alterations is proposed.
ISSN:0309-0167
DOI:10.1111/j.1365-2559.1993.tb00061.x