Optimization of Biopolymer Based Transdermal Films of Metoclopramide as an Alternative Delivery Approach

The objectives of this study were to develop and to characterize sodium alginate based matrix-type transdermal films of metoclopramide hydrochloride (MTC) in order to improve patient compliance to treatment. The suitability of sodium alginate was shown to be a natural film former in terms of the phy...

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Bibliographic Details
Published inPolymers Vol. 6; no. 5; pp. 1350 - 1365
Main Authors Aktar, Betuel, Erdal, Meryem Sedef, Sagirli, Olcay, Guengor, Sevgi, Oezsoy, Yildiz
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.05.2014
Subjects
antiemetic drug
Drugs
Lipids
metoclopramide
natural polymers
Nerolidol
Patients
Permeation
Reflectance
Sodium alginate
Terpenes
transdermal film
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Summary:The objectives of this study were to develop and to characterize sodium alginate based matrix-type transdermal films of metoclopramide hydrochloride (MTC) in order to improve patient compliance to treatment. The suitability of sodium alginate was shown to be a natural film former in terms of the physicochemical, mechanical, and bioadhesive features of the MTC loaded transdermal films. Terpinolene provided the highest drug release among the different terpenes (nerolidol, eucalyptol, dl-limonene, or terpinolene) assessed as enhancer. Attenuated Total Reflectance Infrared (ATR-FTIR) spectroscopy analysis performed to evaluate the effect of the transdermal films on skin barrier confirmed enhancer induced lipid bilayer disruption in stratum corneum, indicating its permeation enhancement effect.
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ISSN:2073-4360
2073-4360
DOI:10.3390/polym6051350