Oestrogen receptor negative-progesterone receptor positive phenotype in 1,211 breast tumours

From 1,211 breast cancers, 15 oestrogen receptor (ER) negative-progesterone receptor (PgR) positive breast cancers by conventional dextran coated charcoal steroid binding assays in cytosol were reassessed using Elisa techniques with monoclonal antireceptors antibodies in the cytosolic and nuclear fr...

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Bibliographic Details
Published inBritish journal of cancer Vol. 65; no. 6; pp. 895 - 897
Main Authors PICHON, M. F, MILGROM, E
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing Group 01.06.1992
Subjects
Adult
Aged
Biological and medical sciences
Breast Neoplasms - chemistry
Breast Neoplasms - diagnosis
Cell Nucleus - chemistry
Cytosol - chemistry
Genital system. Mammary gland
Humans
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Middle Aged
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
Human
Binding
Steroid
Immunocytochemistry
Estrogen
Exploration
Malignant tumor
Enzyme immunoassay
Ovarian hormone
Pathology
Mammary gland diseases
Phenotype
Mammary gland
Progesterone
ELISA assay
Comparative study
Hormonal receptor
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Summary:From 1,211 breast cancers, 15 oestrogen receptor (ER) negative-progesterone receptor (PgR) positive breast cancers by conventional dextran coated charcoal steroid binding assays in cytosol were reassessed using Elisa techniques with monoclonal antireceptors antibodies in the cytosolic and nuclear fractions, and immunocytochemistry on cryostat sections. Three categories of results were found in this series. Two tumours were false negative ER due to receptor sites occupancy by hormonal contraceptive treatment. A second group of ten tumours, with high PgR concentrations and immunoreactive ER, corresponds to non ER-binding forms of receptors. One PgR positive tumour was found to be devoid of PgR by using monoclonal antiPgR antibodies might contain a progesterone binding cyst protein. Only two tumours were found to be true ER negative-PgR positive by all methods. This rare phenotype deserves further study of the regulation of the PgR gene.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1992.187