A Role for siRNA in X-Chromosome Dosage Compensation in Drosophila melanogaster

Sex-chromosome dosage compensation requires selective identification of X chromatin. How this occurs is not fully understood. We show that small interfering RNA (siRNA) mutations enhance the lethality of Drosophila males deficient in X recognition and partially rescue females that inappropriately do...

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Bibliographic Details
Published inGenetics (Austin) Vol. 191; no. 3; pp. 1023 - 1028
Main Authors Menon, Debashish U, Meller, Victoria H
Format Journal Article
LanguageEnglish
Published United States Genetics Society of America 01.07.2012
Subjects
Animals
Chromosomes
Compensation
Dosage Compensation, Genetic - genetics
Drosophila melanogaster - genetics
Drosophila Proteins - deficiency
Drosophila Proteins - genetics
Female
Gene Knockdown Techniques
Genetic research
Male
Mutation
Ribonucleic acid
RNA
RNA, Small Interfering - genetics
RNA-Binding Proteins - genetics
Sexes
Transcription Factors - deficiency
Transcription Factors - genetics
X Chromosome - genetics
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Summary:Sex-chromosome dosage compensation requires selective identification of X chromatin. How this occurs is not fully understood. We show that small interfering RNA (siRNA) mutations enhance the lethality of Drosophila males deficient in X recognition and partially rescue females that inappropriately dosage-compensate. Our findings are consistent with a role for siRNA in selective recognition of X chromatin.
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Supporting information is available online at http://www.genetics.org/content/suppl/2012/05/02/genetics.112.140236.DC1.
ISSN:1943-2631
0016-6731
1943-2631
DOI:10.1534/genetics.112.140236