Mechanistic Insights into MicroRNA-Mediated Gene Silencing

• Published in: Cold Spring Harbor perspectives in biology Vol. 11; no. 3; p. a032771
• Main Authors: Duchaine, Thomas F, Fabian, Marc R
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.03.2019
• Subjects: 3' Untranslated Regions; Animals; Argonaute Proteins - metabolism; Gene expression; Gene Regulatory Networks; Gene Silencing; Humans; MicroRNAs - metabolism; miRNA; mRNA turnover; PERSPECTIVES; Protein biosynthesis; Protein Domains; Protein synthesis; Proteins; Ribonucleic acid; RNA; Shutdowns

MicroRNAs (miRNAs) posttranscriptionally regulate gene expression by repressing protein synthesis and exert a broad influence over development, physiology, adaptation, and disease. Over the past two decades, great strides have been made toward elucidating how miRNAs go about shutting down messenger...