Mechanistic Insights into MicroRNA-Mediated Gene Silencing

MicroRNAs (miRNAs) posttranscriptionally regulate gene expression by repressing protein synthesis and exert a broad influence over development, physiology, adaptation, and disease. Over the past two decades, great strides have been made toward elucidating how miRNAs go about shutting down messenger...

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Bibliographic Details
Published inCold Spring Harbor perspectives in biology Vol. 11; no. 3; p. a032771
Main Authors Duchaine, Thomas F, Fabian, Marc R
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.03.2019
Subjects
3' Untranslated Regions
Animals
Argonaute Proteins - metabolism
Gene expression
Gene Regulatory Networks
Gene Silencing
Humans
MicroRNAs - metabolism
miRNA
mRNA turnover
PERSPECTIVES
Protein biosynthesis
Protein Domains
Protein synthesis
Proteins
Ribonucleic acid
RNA
Shutdowns
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Summary:MicroRNAs (miRNAs) posttranscriptionally regulate gene expression by repressing protein synthesis and exert a broad influence over development, physiology, adaptation, and disease. Over the past two decades, great strides have been made toward elucidating how miRNAs go about shutting down messenger RNA (mRNA) translation and promoting mRNA decay.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a032771