Calcium waves in a grid of clustered channels with synchronous IP3 binding and unbinding
. Calcium signals in cells occur at multiple spatial scales and variable temporal duration. However, a physical explanation for transitions between long-lasting global oscillations and localized short-term elevations (puffs) of cytoplasmic Ca 2+ is still lacking. Here we introduce a phenomenological...
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Published in | The European physical journal. E, Soft matter and biological physics Vol. 39; no. 11; pp. 1 - 11 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.11.2016
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | .
Calcium signals in cells occur at multiple spatial scales and variable temporal duration. However, a physical explanation for transitions between long-lasting global oscillations and localized short-term elevations (puffs) of cytoplasmic Ca
2+
is still lacking. Here we introduce a phenomenological, coarse-grained model for the calcium variable, which is represented by ordinary differential equations. Due to its small number of parameters, and its simplicity, this model allows us to numerically study the interplay of multi-scale calcium concentrations with stochastic ion channel gating dynamics even in larger systems. We apply this model to a single cluster of inositol trisphosphate (
IP
3
) receptor channels and find further evidence for the results presented in earlier work: a single cluster may be capable of producing different calcium release types, where long-lasting events are accompanied by unbinding of
IP
3
from the receptor (Rückl
et al.
, PLoS Comput. Biol.
11
, e1003965 (2015)). Finally, we show the practicability of the model in a grid of 64 clusters which is computationally intractable with previous high-resolution models. Here long-lasting events can lead to synchronized oscillations and waves, while short events stay localized. The frequency of calcium releases as well as their coherence can thereby be regulated by the amplitude of
IP
3
stimulation. Finally the model allows for a new explanation of oscillating [
IP
3
], which is not based on metabolic production and degradation of
IP
3
.
Graphical abstract |
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ISSN: | 1292-8941 1292-895X |
DOI: | 10.1140/epje/i2016-16108-4 |