miR-34b/c rs4938723 T>C Decreases Neuroblastoma Risk: A Replication Study in the Hunan Children

• Published in: Disease markers Vol. 2019; no. 2019; pp. 1 - 6
• Main Authors: Liu, Zan, Xiao, Yaling, Xiao, Zhenghui, Liu, Jiabin, Zhou, Haiyan, Zhuo, Zhen-Jian, Li, Yong, He, Jing
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2019; Hindawi; John Wiley & Sons, Inc
• Subjects: Adrenal Gland Neoplasms - diagnosis; Adrenal Gland Neoplasms - ethnology; Adrenal Gland Neoplasms - genetics; Adrenal Gland Neoplasms - pathology; Age; Alleles; Asian Continental Ancestry Group; C gene; Case-Control Studies; Child, Preschool; Children; Colorectal cancer; Esophagus; Female; Females; Gender; Gene Expression Regulation, Neoplastic; Gene Frequency; Gene polymorphism; Genes; Genetic Predisposition to Disease; Genetics; Genotype & phenotype; Genotyping; Humans; Infant; Infant, Newborn; Liver cancer; Logistic Models; Male; Males; Mediastinal Neoplasms - diagnosis; Mediastinal Neoplasms - ethnology; Mediastinal Neoplasms - genetics; Mediastinal Neoplasms - pathology; Medical research; MicroRNAs; MicroRNAs - genetics; Mutation; Neuroblastoma; Neuroblastoma - diagnosis; Neuroblastoma - ethnology; Neuroblastoma - genetics; Neuroblastoma - pathology; Odds Ratio; Pathogenesis; Polymorphism; Regression analysis; Replication; Retroperitoneal Neoplasms - diagnosis; Retroperitoneal Neoplasms - ethnology; Retroperitoneal Neoplasms - genetics; Retroperitoneal Neoplasms - pathology; Risk; Risk factors; Statistical analysis; Subgroups; Tumors; China
• ISSN: 0278-0240; 1875-8630; 1875-8630
• DOI: 10.1155/2019/6514608

Neuroblastoma is the most common seen solid neural tumor in children less than age one. As mutation in the miR-34b/c gene is observed in several types of human malignancies, there likely to be similar events that contribute to the pathogenesis of neuroblastoma. We hypothesize that polymorphism in the miR-34b/c gene might predispose to neuroblastoma. Here, we conducted this replication study by genotyping rs4938723 T>C from miR-34b/c in Hunan children (162 subjects with neuroblastoma and 270 control subjects) and examined its effect on the risk of neuroblastoma. We determined such association using logistic regression, adjusted for age and gender. Relative to those with TT genotype, subjects with C allele had reduced neuroblastoma risk (TC vs. TT: adjusted OR=0.46, 95%CI=0.30‐0.71; additive model: adjusted OR=0.64, 95%CI=0.47‐0.88; TC/CC vs. TT: adjusted OR=0.49, 95%CI=0.33‐0.73). Stratified analysis revealed that rs4938723 TC/CC carriers were less likely to develop neuroblastoma for patients in the subgroups of age≤18 months, age>18 months, females, males, tumors in retroperitoneal, tumors in other sites, and clinical stages II, III, IV, and III+IV. Our findings verified miR-34b/c rs4938723 C variant allele as a protective factor for the risk of neuroblastoma. Further investigation of how miR-34b/c rs4938723 T>C might modify neuroblastoma risk is warranted.