Effect of Selected Metal Ions on the Photodegradation of Ciprofloxacin in the Solid Phase

The photodegradation of ciprofloxacin in the solid phase was investigated by using the chromatographic-densitometric method in the presence and absence of selected metal ions. It was shown that both ion concentration and ion type have an effect on the degradation process that leads to the generation...

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Bibliographic Details
Published inJournal of AOAC International Vol. 91; no. 6; pp. 1331 - 1338
Main Authors HUBICKA, Urszula, KRZEK, Jan
Format Journal Article
LanguageEnglish
Published Gaithersburg, MD AOAC International 01.11.2008
Oxford University Press
Subjects
Anti-Infective Agents - chemistry
Anti-Infective Agents - radiation effects
Biological and medical sciences
Chromatography
Chromatography, High Pressure Liquid
Ciprofloxacin
Ciprofloxacin - chemistry
Ciprofloxacin - radiation effects
Densitometry
Food industries
Fundamental and applied biological sciences. Psychology
Indicators and Reagents
Kinetics
Metal ions
Metals - chemistry
Photochemistry
Photodegradation
Properties
Ultraviolet Rays
United States
Metal ion
Solid phase
Ciprofloxacin
Photochemical degradation
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Summary:The photodegradation of ciprofloxacin in the solid phase was investigated by using the chromatographic-densitometric method in the presence and absence of selected metal ions. It was shown that both ion concentration and ion type have an effect on the degradation process that leads to the generation of 2 new products with R(f) values of approximately 0.45 and 0.56, which are different from the R(f) of approximately 0.68 for ciprofloxacin. It was found that CU2+ and Fe3+ ions have the strongest effect on ciprofloxacin photodegradation compared with photodegradation carried out without these ions and also with photodegradations carried out in the presence of Zn2+, Cr3+, Ni2+, and Co2+ ions. To identify the photodegradation products, we used amine-specific chromatographic reactions, UV spectra recorded directly from the chromatograms, and proton nuclear magnetic resonance and IR spectroscopic methods. The chemical structures of the degradation products were found to be 7-[(2-aminoethyl)amino]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid and 7-amino-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1060-3271
1944-7922
DOI:10.1093/jaoac/91.6.1331